Yes, says a well-written piece in this edition of Lancet Global Health. There is, it argues, no realistic alternative: the parasites will become drug resistant and the vectors resistant to insecticides. The opinion piece is beautifully constructed but makes a few assertions that are far from self-evident: deployment of the current RTS,S vaccine (with efficacy of about 30 percent) will “start a journey towards other and better vaccines”, for example. Still, with a lot of money, they think that malaria could be eradicated by 2050 or 2060. The cynics among us will remember that Richard Nixon thought cancer could be cured by the 1990s and the US Government was quite sure that it would have an HIV vaccine by the end of the 1980s.